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Date: 7-7-2019
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To resolve a racemic alcohol, a chiral acid can be used to convert the alcohol to a mixture of diastereomeric esters. This is not as generally useful as might be thought because esters tend to be liquids unless they are very high-molecularweight compounds. If the diastereomeric esters are not crystalline, they must be separated by some other method than fractional crystallization (for instance, by chromatography methods, Section 9-2). Two chiral acids that are useful resolving agents for alcohols are:
The most common method of resolving an alcohol is to convert it to a half-ester of a dicarboxylic acid, such as butanedioic (succinic) or 1,2-benzenedicarboxylic (phthalic) acid, with the corresponding anhydride. The resulting half-ester has a free carboxyl function and may then be resolvable with a chiral base, usually brucine:
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