The science which is perhaps the most deeply affected by physics is chemistry. Historically, the early days of chemistry dealt almost entirely with what we now call inorganic chemistry, the chemistry of substances which are not associated with living things. Considerable analysis was required to discover the existence of the many elements and their relationships—how they make the various relatively simple compounds found in rocks, earth, etc. This early chemistry was very important for physics. The interaction between the two sciences was very great because the theory of atoms was substantiated to a large extent by experiments in chemistry. The theory of chemistry, i.e., of the reactions themselves, was summarized to a large extent in the periodic chart of Mendeleev, which brings out many strange relationships among the various elements, and it was the collection of rules as to which substance is combined with which, and how, that constituted inorganic chemistry. All these rules were ultimately explained in principle by quantum mechanics, so that theoretical chemistry is in fact physics. On the other hand, it must be emphasized that this explanation is in principle. We have already discussed the difference between knowing the rules of the game of chess, and being able to play. So it is that we may know the rules, but we cannot play very well. It turns out to be very difficult to predict precisely what will happen in a given chemical reaction; nevertheless, the deepest part of theoretical chemistry must end up in quantum mechanics.

There is also a branch of physics and chemistry which was developed by both sciences together, and which is extremely important. This is the method of statistics applied in a situation in which there are mechanical laws, which is aptly called statistical mechanics. In any chemical situation a large number of atoms are involved, and we have seen that the atoms are all jiggling around in a very random and complicated way. If we could analyze each collision, and be able to follow in detail the motion of each molecule, we might hope to figure out what would happen, but the many numbers needed to keep track of all these molecules exceeds so enormously the capacity of any computer, and certainly the capacity of the mind, that it was important to develop a method for dealing with such complicated situations. Statistical mechanics, then, is the science of the phenomena of heat, or thermodynamics. Inorganic chemistry is, as a science, now reduced essentially to what are called physical chemistry and quantum chemistry; physical chemistry to study the rates at which reactions occur and what is happening in detail (How do the molecules hit? Which pieces fly off first? etc.), and quantum chemistry to help us understand what happens in terms of the physical laws.

The other branch of chemistry is organic chemistry, the chemistry of the substances which are associated with living things. For a time, it was believed that the substances which are associated with living things were so marvelous that they could not be made by hand, from inorganic materials. This is not at all true—they are just the same as the substances made in inorganic chemistry, but more complicated arrangements of atoms are involved. Organic chemistry obviously has a very close relationship to the biology which supplies its substances, and to industry, and furthermore, much physical chemistry and quantum mechanics can be applied to organic as well as to inorganic compounds. However, the main problems of organic chemistry are not in these aspects, but rather in the analysis and synthesis of the substances which are formed in biological systems, in living things. This leads imperceptibly, in steps, toward biochemistry, and then into biology itself, or molecular biology.