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Date: 5-8-2018
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Date: 25-5-2017
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Date: 21-8-2016
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Both ‘Grignard reagents’ and organolithiums are particularly useful in nucleophilic addition reactions with carbonyl electrophiles, such as ketones:
The nucleophilic carbon need not be primary as in the picture above. The synthesis of 2-phenyl-2-propanol, for example, can be carried by reacting phenylmagnesium bromide with acetone.
Addition to formaldehyde gives 1o alcohols