Miscibility

Solvent manufacturer Honeywell Burdick & Jackson defines solvents as miscibleif the two components can be mixed together in all proportions without forming two separate phases. A solvent miscibility chart (Figure 1.1) is a useful aid for determining which solvent pairs are immiscible and would therefore be potential candidates for use in LLE. More solvent combinations are miscible than immiscible, and more solvents are immiscible with water than with any other solvent. Solvents miscible with water in all proportions include acetone, acetonitrile, dimethyl acetamide, N,Ndimethylformamide, dimethyl sulfoxide, 1,4-dioxane, ethyl alcohol, glyme, isopropyl alcohol, methanol, 2-methoxyethanol, N-methylpyrrolidone, npropyl alcohol, pyridine, tetrahydrofuran, and trifluoroacetic acid.

Figure 1.1.Solvent miscibility chart. http://www.bandj.com/BJProduct/SolProperties/Miscibility.htm