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Date: 21-8-2016
2421
Date: 10-7-2016
2648
Date: 8-10-2018
1627
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The acidity of terminal alkynes also plays a role in product determination when vicinal (or geminal) dihalides undergo base induced bis-elimination reactions. The following example illustrates eliminations of this kind starting from 1,2-dibromopentane, prepared from 1-pentene by addition of bromine. The initial elimination presumably forms 1-bromo-1-pentene, since base attack at the more acidic and less hindered 1 º-carbon should be favored. The second elimination then produces 1-pentyne. If the very strong base sodium amide is used, the terminal alkyne is trapped as its sodium salt, from which it may be released by mild acid treatment. (NB One cannot stop the reaction at the terminal alkyne with 2 equivalents of strong base.) However, if the weaker base KOH with heat is used for the elimination, the terminal alkyne salt is not formed, or is formed reversibly, and the initially generated 1-pentyne rearranges to the more stable 2-pentyne via an allene intermediate.
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إدارة الغذاء والدواء الأميركية تقرّ عقارا جديدا للألزهايمر
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شراء وقود الطائرات المستدام.. "الدفع" من جيب المسافر
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بالصور: الامين العام للعتبة الحسينية المقدسة يجري جولة ميدانية للوقوف على آخر الاستعدادات الخاصة بمراسيم تبديل راية الإمام الحسين (ع)
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