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Date: 1-9-2019
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Date: 10-3-2016
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Acid (acyl) chlorides can be converted to aldehydes using lithium tri-tert-butoxyaluminium hydride (LiAlH(Ot-Bu)3). The hydride source (LiAlH(Ot-Bu)3) is a weaker reducing agent than lithium aluminum hydride. Because acid chlorides are highly activated they still react with the hydride source; however, the formed aldehyde will react slowly, which allows for its isolation.
General reaction:
Acid chlorides can be converted to aldehydes using lithium tri-tert-butoxyaluminium hydride (LiAlH(Ot-Bu)3). The hydride source (LiAlH(Ot-Bu)3) is a weaker reducing agent than lithium aluminum hydride. Because acid chlorides are highly activated they still react with the hydride source; however, the formed aldehyde will react slowly, which allows for its isolation.
General Reaction:
Esters can be converted to aldehydes using diisobutylaluminium hydride (DIBAH). The reaction is usually carried out at -78 oC to prevent reaction with the aldehyde product.
Esters can be converted to 1o alcohols using LiAlH4, while sodium borohydride (NaBH4
) is not a strong enough reducing agent to perform this reaction.
1) Nucleophilic attack by the hydride
2) Leaving group removal
3) Nucleophilic attack by the hydride anion
4) The alkoxide is protonated
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حمية العقل.. نظام صحي لإطالة شباب دماغك
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إيرباص تكشف عن نموذج تجريبي من نصف طائرة ونصف هليكوبتر
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شعبة مدارس الكفيل النسوية تطلق فعّاليات مخيم (بنات العقيدة) العشرين
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قسم التربية والتعليم يعقد اجتماعاً تحضيرياً لملاكاته استعداداً لانطلاق برنامجه التأهيلي
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متحف الكفيل يعقد أولى اجتماعاته التحضيرية لمؤتمره الدوليّ الخامس
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وفد قسم الشؤون الفكرية وسفير العراق في فرنسا يبحثان سبل تعزيز التعاون المشترك
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