Superior vena cava obstruction (SVCO) is a common complication of cancer that can occur through extrinsic compression or intravascular blockage. The most common causes of extrinsic compression are lung cancer, lymphoma and metastatic tumours (Fig. 1). Patients with cancer can also develop SVCO due to intravascular blockage in association with a central catheter or thromboembolism secondary to the tumour.

fig1. Computed tomography (CT) image of extrinsic compression of the superior vena cava by a small cell lung cancer (arrow) performed as part of investigations for an acute presentation of cancer.

Clinical features

The classical presentation is with breathlessness, oedema of the arms and face, distended neck and arm veins and dusky skin coloration over the chest, arms and face. Collateral vessels may develop over a period of weeks and the flow of blood in the collaterals helps to confirm the diagnosis. Headache secondary to cerebral oedema arising from the back flow pressure may also occur and tends to be aggravated by bending forwards, stooping or lying down. The severity of symptoms is related to the rate of obstruction and the development of a venous collateral circulation. Accordingly, symptoms may develop rapidly or gradually. Clinical features are summarised in Box 1.

Box1. Common symptoms and physical findings in superior vena cava obstruction*

Investigations and management

 The investigation of choice is a CT scan of the thorax to confirm the diagnosis and distinguish between extra- and intravascular causes.

 A biopsy should be obtained when the tumour type is unknown because tumour type has a major influence on treatment. CT of the head may be indicated if cerebral oedema is suspected. Tumours that are exquisitely sensitive to cytotoxic chemotherapy, such as germ cell tumours and lymphoma, can be treated with cytotoxic chemotherapy alone. For most other patients with symptomatic SVCO, SVC stenting provides the best outcomes although mediastinal radiotherapy may also be considered. Where possible, these measures should be followed by treatment of the primary tumour, as long-term outcome is strongly dependent on the prognosis of the underlying cancer.

مواضيع ذات صلة

السرطان اللبي ( النخاعي ) Medullary carcinoma

Hepatocellular carcinoma (liver cell cancer)

تدبير سرطانات الدرق المتمايزة بعد الجراحة

السرطان الحليمي Papillary carcinoma

العقدة الدرقية الوحيدة

السلعة السمية متعددة العقد Toxic multinodular goiter

Colorectal carcinoma

Colorectal polyps

Breast cancer

أورام الغدد اللعابية

الكيسات الغلصمية Branchial cleft cysts

الكيسة الدرقية اللسانية