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Date: 1-10-2019
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Date: 24-9-2020
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Date: 2-10-2018
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General Reactions of Carbonyl Compounds
A “nucleophilic addition reaction” (of a carbonyl compound) involves the initial attack of a nucleophile on the slightly positive carbonyl‑carbon atom to form a tetrahedral intermediate.
In a “nucleophilic acyl substitution reaction,” a nucleophile attacks the carbonyl carbon of a carboxylic acid derivative
and initially produces a tetrahedral intermediate. The intermediate then reacts by expelling the leaving group, X, thereby forming a new carboxylic acid derivative.
In an “alpha substitution reaction” of a carbonyl compound, one of the hydrogen atoms attached to a carbon atom adjacent to the carbonyl group is removed and replaced by some other group.
Alpha substitution reactions of carbonyl compounds involve the “enol” form of the compound. Keto‑enol tautomerism was briefly introduced in Section 9.4. Review this section if necessary.
As you can see from the above diagram, the enol form has a hydroxyl group attached to one of the s p2 ‑hybridized carbon atoms of a carbon‑carbon double bond. Removal of the proton from the hydroxyl group produces a resonance‑stabilized “enolate anion”:
A “carbonyl condensation reaction” is one in which two carbonyl‑ containing molecules condense together (i.e., join together), often with the elimination of water. The reaction involves the formation of an enolate anion from one carbonyl‑containing molecule, followed by the subsequent nucleophilic attack by this enolate anion on the carbonyl carbon atom of the second molecule.
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تجربة بسيطة مدتها 3 دقائق تحسن النظر كثيرا
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الصين.. تطوير محفز نانوي رخيص الثمن لتنقية المياه من النترات
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بحضور علمائي ورسمي .. العتبة العلوية المقدسة ترفع راية الحزن والحداد إيذاناً بحلول شهر محرم الحرام
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