تسجيل الدخول

تسجيل

Antimicrobial Susceptibility Testing and Therapy of Haemophilus

المؤلف:  Patricia M. Tille, PhD, MLS(ASCP)

المصدر:  Bailey & Scotts Diagnostic Microbiology

الجزء والصفحة:  13th Edition , p407-409

2026-05-21

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Standard methods have been established for performing in vitro susceptibility testing with clinically relevant isolates of Haemophilus spp. In addition, various agents may be considered for testing and therapeutic use (Table 1). Although widespread H. influenzae is capable of producing beta-lactamase (penicillin resistance), third-generation cephalosporins are not notably affected by the enzyme (i.e., ceftriaxone and cefotaxime) and may be effective therapeutic agents. Therefore, routine susceptibility testing of clinical isolates as a guide to therapy may not be necessary. Care should be taken when preparing inoculum concentrations (0.5 McFarland) for Haemophilus spp.; in particular, beta- lactamase-producing strains of H. influenzae, as higher suspensions may lead to false-resistant results.

Table1.  Antimicrobial Therapy and Susceptibility Testing