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Transition metals extend the range of organic reactions

المؤلف:  Jonathan Clayden , Nick Greeves , Stuart Warren

المصدر:  ORGANIC CHEMISTRY

الجزء والصفحة:  ص1069-1070

2025-08-06

498

Transition metals extend the range of organic reactions

Some of the most exciting reactions in organic chemistry make use of transition metals, and in recent years three Nobel prizes have been awarded for work in this area. How about this example? It is a Heck reaction, which allows nucleophilic addition to an unactivated alkene. Just a catalytic amount of palladium is needed to make the reaction go: the most useful organometallic reactions are those in which the metal acts catalytically.

Reagents and complexes containing transition metals are important in modern organic syn thesis because they allow apparently impossible reactions to occur easily. Their chemistry complements traditional functional group chemistry and significantly broadens the range of reactions a chemist can expect to use to make molecules. This chapter introduces the con-cepts of metal–ligand interaction, describes the most important reactions that can occur while ligands are bound to the metal, and demonstrates the power of organometallic chemistry in synthesis. The efficiency of transition metal-catalysed reactions means that they are routinely used in industrial synthesis. It is important that you understand the rules by which organometallic chemistry works.