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Date: 16-1-2016
2007
Date: 16-1-2016
1560
Date: 6-12-2015
1420
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Lipoproteins Metabolism
Plasma lipoprotein are in a dynamic state. Their continuous synthesis and degradation are accompanied by rapid exchanges of lipid and protein components between the different lipoprotein classes. Major sites of plasma lipoprotein synthesis are liver and intestine. The necessary components are triacylglycerols, cholesterol (and cholesterol esters), phospholipids and apoproteins. Three enzymes play an important role in the delivery, storage and mobilization of lipoproteins and cholesterol:
Insulin increases LPL activity in adipose tissue (but not in muscles) So after a meal, insulin released promotes fuel storage as triacylglycerols in adipose tissue. During starvation, activity of LPL in adipose tissue is low whereas activity of the heart enzyme is high. FFA released from VLDL are used by the heart as a fuel.
- In general, LPL has different functions in different tissues:
This reaction is responsible for formation of cholesterol esters in plasma. So, LCAT plays a significant role in removal of cholesterol from the circulating lipoproteins similar to the role of LPL in removal of triacylglycerol from chylomicrons and VLDL.
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