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oxicological screening , Other NSAIDs

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  233

2026-10-18

50

oxicological screening

Other NSAIDs

Other NSAIDs include the arylacetic acids (e.g. diclofenac), arylpropionic acids (e.g. ibuprofen, ketoprofen, naproxen), heterocyclic acetic acids (e.g. indometacin, ketorolac, sulindac), pyrazolones (phenylbutazone), oxicams (e.g. piroxicam) and mefenamic acid. Most patients who take an overdose of these drugs are asymptomatic, but the chronic use of mixtures of analgesic drugs has been linked to renal damage, including papillary necrosis and chronic interstitial nephritis. Most of these classic NSAIDs were replaced by an increasing number of cyclooxygenase inhibitors (COX-1 and COX-2) but their cardiotoxicity has dramatically decreased their use. These compounds are extractable at acidic pH values and most can be determined by the STIP method or other suitable HPLC methods.