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Epidemiology of Paget’s disease of Bone

المؤلف:  Wass, J. A. H., Arlt, W., & Semple, R. K. (Eds.).

المصدر:  Oxford Textbook of Endocrinology and Diabetes

الجزء والصفحة:  3rd edition , p751

2026-07-05

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 Paget’s disease affects typically older people, slightly more men than women, and seldom presents before the age of 35 years. Its prevalence increases with age and it affects 1 to 5% of those above 50 years of age. However, only a small proportion of individuals with Paget’s disease comes to clinical attention, most commonly these with symptomatic or severe disease. There is a dis tinct geographical distribution; the disease is common in central, western, and parts of southern Europe, the United States, Australia, New Zealand, and some countries of South America, while it is un common in Scandinavia, Asia, and Africa. There may also be variations in prevalence in regions within the same country. For example, in northeast USA the prevalence is about fivefold higher than in south USA and in parts of northwest England in 1974 the age- and gender- standardized prevalence rate was 8.3% compared to 4.6% in southern towns and cities. Notably, a more recent radiographic survey in the same centres with identical methodology reported a decline in the overall prevalence of the dis ease, as has also been observed in other, but not all, countries where comparative studies were performed. In addition, reports from New Zealand, United Kingdom, and Spain suggested that the clinical se verity of the disease has attenuated in recent years. These changes in prevalence and severity of the disease strongly suggest that environmental factors are involved in its pathogenesis.