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Epidemiology of Hypocalcaemia

المؤلف:  Wass, J. A. H., Arlt, W., & Semple, R. K. (Eds.).

المصدر:  Oxford Textbook of Endocrinology and Diabetes

الجزء والصفحة:  3rd edition , p685

2026-06-24

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Relatively few studies have described the epidemiology of hypocalcaemia, hypoparathyroidism, or pseudohypoparathyroidism. A recent large internal medicine hospital series including 30 813 patients showed that 3% had recognized hypocalcaemia at hospital admission. Post- thyroid surgical clinical series describe transient hypocalcaemia in 25.4– 83% of patients, with chronic hypocal caemia more than 6 months after surgery occurring in 0.12– 4.6%.

The prevalence of chronic hypoparathyroidism has been reported from various European countries and the United States to range between 10.1/ 100 000 in Norway, and 40/ 100 000 in Tayside, Scotland. Most studies have shown the prevalence to be in the 20– 30/ 100 000 range. Only two studies have evaluated the incidence of hypoparathyroidism. One study in Denmark estimated the incidence to be 0.8/ 100 000/ year, and the other study in India estimated the incidence to be 2.6/ 100 000/ year.

The best prevalence estimate of chronic hypoparathyroidism in the United States is based on analysis of a large health plan claims database, which identified a total of 77 000 cases. The longitudinal population- based Rochester Epidemiology Project was used to derive a prevalence estimate of 37/ 100 000. In the nationwide Danish historic cohort study, the prevalence of postsurgical hypoparathyroidism was estimated to be 22/ 100 000, with the prevalence of non- surgical hypoparathyroidism 2.3/ 100 000. The study of hospitalized patients with hypoparathyroidism in Norway showed the prevalence of postsurgical hypoparathyroidism to be 6.4/ 100 000, and non- surgical hypoparathyroidism 3.0/ 100 000.

The same Norwegian study estimated the prevalence of pseudohypoparathyroidism to be 0.8/ 100 000. The same study in India estimated the incidence of pseudohypoparathyroidism to be 0.16/ 100 000/ year.